Graduate University of Groningen. Worked as a chemist in companies such as Wilmar Oleochemicals B.V (Botlek Rotterdam) and SABIC (Bergen op Zoom)

MDP2NP

Contents hide

1 Synthesis and Physico-Chemical Properties of MDP2NP

2 Abstract

3 General Information [1-4]

4 Physico-Chemical Properties of MDP2NP [1-4]

5 Applications of MDP2NP

6 Chemical Reactions

7 Conclusion

8 Bibliography

Synthesis and Physico-Chemical Properties of MDP2NP

Abstract

This article presents a comprehensive overview of MDP2NP, a key precursor for MDA and MDMA production, including its general information, physico-chemical properties, chemical reactions, synthesis, conclusion and bibliography.

General Information [1-4]

Other synonyms: 5-(2-Nitroprop-1-en-1-yl)benzo[d][1,3]dioxole; 5-(2-Nitro-1-propenyl)-1,3-benzodioxole; 3,4-methylenedioxyphenyl-2-nitropropene; 1-MPNP;

IUPAC Name: 5-(2-nitroprop-1-enyl)-1,3-benzodioxole

CAS Number: 5438-41-5

Physico-Chemical Properties of MDP2NP [1-4]

Molecular Formula C₁₀H₉NO₄
Molar Weight 207.18 g/mol
Melting Point 93-98 ℃ and 91 ℃
Solubility: soluble in EtOH, MeOH, IPA, DCM, acetic acid; non soluble in water
Color/Form: bright yellow crystals

Structural formula

Figure 1. Structure of MDP2NP — **Figure 1. Structure of** **MDP2NP**

Figure 2. Crystalline solid of MDP2NP — **Figure** **2. Crystalline solid of MDP2NP**

Applications of MDP2NP

3,4-Methylenedioxyphenyl-2-nitropropene serves as a key precursor for the synthesis of MDP2P, MDA and MDMA. This nitropropene should be utilized within one week or kept in a cold environment, as it gradually turns to a pale orange color at room temperature over the course of a few weeks, indicating it is beginning to break down.

Chemical Reactions

**Figure 3. MDP2P formation from MDP2NP**

Figure 4. Reduction to MDA. MDP2NP — **Figure 4. Reduction to MDA**. MDP2NP

Figure 5. Full reduction of MDP2NP — **Figure 5. Full reduction** **of MDP2NP**

A solution of piperonal in glacial acetic acid was combined with nitroethane, followed by the addition of cyclohexylamine. The mixture was heated on a steam bath for 6 hours, then diluted with water, seeded with a crystal of the product, and left to cool overnight at 10 °C. Bright yellow crystals formed, which were filtered and air-dried to yield 1-(3,4-methylenedioxyphenyl)-2-nitropropene, with a melting point of 93–94 °C. Recrystallization from acetic acid improved the melting point to 97–98 °C. Attempts to synthesize the nitrostyrene using nitroethane in excess as a solvent and anhydrous ammonium acetate as the base resulted in low yields and impure product. Alternatively, successful preparation of the nitrostyrene was achieved by combining the components in cold methanol, using aqueous sodium hydroxide as the base.

**Figure 6. General scheme of MDP2NP synthesis**

Conclusion

Synthesis of MDP2NP [1, 5, 6] serves as an important precursor in the synthesis of both MDA (3,4-methylenedioxyamphetamine) and MDMA (3,4-methylenedioxymethamphetamine), which are compounds of significant interest in both pharmacological research and illicit drug production. Due to its molecular structure, MDP2NP is highly reactive and unstable, which poses challenges in its handling and storage. This instability is often attributed to the nitro group present in its structure, making it prone to decomposition under certain conditions. Additionally, the instability of MDP2NP may affect the efficiency of subsequent synthetic steps, necessitating careful optimization of reaction conditions in its preparation.

Bibliography

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